What major challenge has arisen due to the overuse of antibiotics?

The development of antibiotics in the 20th century revolutionized medicine, dramatically reducing mortality rates from bacterial infections. Penicillin, discovered by Alexander Fleming, was among the first and most impactful. However, the overuse and misuse of antibiotics have led to the rise of antibiotic-resistant bacteria, posing a significant global health challenge and necessitating responsible prescribing practices.